Dissolution of Spike Protein by Nattokinase --- A caution

Some doctors and scientists end up in the business of selling supplements, vitamins, even superfoods. If you agitate against vaccination against a dangerous virus that caused a pandemic, killing millions of people, you have already been in trouble, but you do have an audience. An audience that has been exposed to much mis- and disinformation. Unfortunately, some more is added.

"Far and away the most common question I get from those who took one of the COVID-19 vaccines is: “How do I get this out of my body?”

This is not a very scientific question: mRNA is very unstable and disappears in a matter of hours to days, unable to be used as template to make Spike protein. In the COVID-19 vaccines it is administered in lipid nanoparticles (LNPs) to swiftly enter the first cells it encounters.
Best to up the antics a bit then?

"The mRNA and adenoviral DNA products were rolled out with no idea on how or when the body would ever breakdown the genetic code. The synthetic mRNA carried on lipid nanoparticles appears to be resistant to breakdown by human ribonucleases by design so the product would be long-lasting and produce the protein product of interest for a considerable time period. "

​Now we know this is not true. (1) (2) (3); but not everyone knows that. But you can push this and claim it is a problem?

"However, it is a big problem when the protein is the pathogenic SARS-CoV-2 Spike. "

Now you have warmed up your audience, going for the solution! Of course, it happens to be in stock, at a reasonable price....

"The greatest hope for detoxification is a proteolytic agent such as nattokinase, a natural product derived from the fermentation of soy."

Oh dear "detoxification" of something that is not there. For good measure "natural" thrown is thrown in, like as if the totally natural cyanide is a health benefit.

What is nattokinase? Sounds excotic, and it is! It is a protein derived from a dish consumed in Japan, called nattõ: boiled fermented soybeans. Yes, soybeans that have undergone fermentation with the help of specific bacteria; Bacillus subtilis. It has a ammonia-like smell, many say it is smelly, and a mucus-like consistency: not to everyone's taste!

(Image credit: Kuppa_rock/Getty Images)

The traditional breakfast dish, dating back to around 700 AD, is liked by 62% of Japanese people. But, 13% dislike it. Yet, many eat it because it is supposed to have health benefits: it is said to improve blood flow and reduce the risk of stroke: keeping death away. Now, there is a long history, going back to the beginning of the 20th century and involving many eminent scientists, to now that does show that fermented foods may have health benefits: including nattõ. It may depend on its mix of iron, protein, high vitamine E, K and B6, and especially its high fibre content.

"a higher intake of fermented soy was associated with a lower risk of mortality. A significant association between intake of total soy products and all cause mortality was not, however, observed. The findings should be interpreted with caution because the significant association of fermented soy products might be attenuated by unadjusted residual confounding."

But back to the protein, nattokinase. Like anything, it is widely available on the internet in pill form. It is advertised to prevent cardiovascular diseases including heart disease, high blood pressure, high cholesterol, and stroke. BUT: there is no solid scientific data to support these claims.  So, why not add another one:

"Degradation of the Spike protein without damage to cells and tissues can be viewed as a therapeutic goal for the vaccine injured. With the respiratory infection, Spike is processed and activated by cellular proteases including transmembrane serine protein 2 (TMPRSS2), cathepsin, and furin. With vaccination, these systems may be avoided by systemic administration and production of Spike protein within cells. "

Here your heart just skips a beat! A "clever" mix of half-truths and a lie. Spike protein is processed, and rapidly cleared. The cells producing it will be killed by your immune system, just like when they are infected with a virus. We also have enzymes that process Spike; SARS-CoV-2 makes use of these to enter our cells. But, now the killer; "With vaccination, these systems may be avoided by synthetic administration and production of Spike protein within our cells". One could argue that the mRNA is synthetic; it is made in vitro, but by similar enzymes. It is made much like our own mRNA; it has to be, otherwise our enzymes, ribosomes, would not recognise and use it to translate it into protein. BUT: they are your own cells that make Spike! There is absolutely nothing synthetic about that, and it will be recognised by your own enzymes, of course. 

But, you have a product. So, you come up with scientific literature. First this paper, If you add nettõ or nettokinase to Petri dishes, it can dissolve fibrin. Interesting, but still far removed from any clinical use. This paper has this as only figure, Figure 1 is a picture of nettõ, Figure 2 is the Petri dish, Figure 3 a schedule and, Figure 4 is advertisement for nettokinase pills! There are several papers from 1990, no strong solid scientific data; besides a hint of fibrinolytic activity; preliminary indication to prevent deep vein thrombosis and lower blood pressure. All need clinical studies. 
There has not been solid studies on cancer either, although it is claimed that nettokinase helps against that as well.  It could also increase risk of bleeding.

Now we have a pandemic, so someone was bound to try nettokinase: and they did.
"When cell lysates transfected with S protein were incubated with nattokinase, the S protein was degraded in a dose- and time-dependent manner." So, an in vitro study; that is all it shows. A previous study, shows exactly that in total nattõ extracts: in vitro. This is the result of the protease activity of nettokinase. Whether that is of therapeutic use, is quite something else.

But: "Thus, an empiric starting dose could be 2000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent antiplatelet and anticoagulant drugs." that is a dangerous recommendation, trying to soften it a bit at the end. It is dangerous because it is utterly unnecessary to deal with any vaccine Spike protein since it is rapidly cleared (except were needed on fDC to enable good antibody production). It is not responsible to recommend a substance that has not been tested for this purpose and for which there is no clinical data that it even can achieve this. It is also not responsible to use this in case of SARS-CoV-2 infection, its potential anti-coagulation properties and unknown interactions with other processes and medication make this a very risky undertaking.

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Please do not use this for any vaccine issues.